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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-351238 |
NBP1-00739 |
Active Caspase 2 Antibody//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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Active Caspase 2 Antibody |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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ELISA, IHC-P, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Mu, Hu | | Applications: | IHC, WB, ELISA | | Clonality: | Polyclonal | | | Gene: | CASP2 | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | | Specificity: | Caspase 2 (K136) detects endogenous levels of Caspase 2 protein. | Details: Gene Symbol: CASP2 | Entrez: | 835 (Human) | | Related Genes: | CASP3, CASP9, CASP8, CASP1, CYCS, BCL2L1, BCL2, CASP7, BAX, PARP1, BID, CASP6, CRADD, FAS, TP53, ICH-1, LRDD, COL11A2, APAF1, FASLG, DIABLO, BAK1, FADD, TNFSF10, AIFM1, MAPK8, TNF, CDKN1A, CUX1, CASP10, MCL1, CRTAP, CYTIP, NFKB1, GZMB, RIPK1, AKT1, XIAP, JUN, HTT | Background: Caspase-2 (Nedd2, ICH-1) is an aspartate-specific cysteine protease that is activated in response to various apoptotic stimuli. Caspase-2 is unique among the caspases in that it has features of both upstream caspases (long prodomain) and downstream caspases (DEXD substrate specificity). Caspase-2 is highly expressed in the brain during development and is expressed at low levels in adult tissue. Specifically, caspase-2 localizes to the mitochondria, the Golgi, the cytoplasm and the nucleus. Caspase-2 exists as two isoforms, caspase-2L and caspase-2S, which are produced by alternative splicing and differ in their N- and C-termini. Caspase-2L acts as a positive regulator of apoptosis, whereas caspase-2S functions as a negative regulator of apoptosis. Following apoptotic stimuli, the caspase-2L precursor undergoes cleavage at Asp 153 to produce a fragment (p30). The p30 fragment undergoes further cleavage to generate a fragment containing amino acids 153-308 (p18) and a fragment containing amino acids 317-435 (p13 or p14). As apoptosis progresses, the p13 (p14) fragment can undergo further processing to yield a fragment containing amino acids 331-435 (p12). Species: | Reactivity: | This antibody is reactive against Human, Mouse, | Applications: | Uses: | This antibody is useful for the following applications and dilutions:ELISA 1:5000-1:10000,Western Blot 1:500-1:1000,immunohistochemistry 1:50-1:200, | | Dilutions: | ELISA 1:5000-1:10000,Western Blot 1:500-1:1000,immunohistochemistry 1:50-1:200, | | Concentrations: | 1.0 mg/ml | Packaging: | Buffer: | Phosphate buffered saline, pH 7.2. | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | 15mM Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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