| Synonyms | Tartrate-resistant acid phosphatase type 5, TRAP5 |
| Swiss Prot Num | P13686 |
| Immunogen | Recombinant protein corresponding to N-terminal region of human TRAP |
| Product Type | Antibodies |
| Storage | Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Fleckenstein E, et al. (1997) Leukemia, 11:10-13. 2. Hoyer J D, et al. (1997) Am J Clin Pathol, 108:308-315. |
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| Format | State: Liquid tissue culture supernatant |
| ? | Buffer System: 0.09 % sodium azide |
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| Specificity | This antibody detects TRAP. |
| Add. information | Cellular Localization: Cytoplasmic |
| Application | Immunohistology (Formalin/paraffin): 1:20 for 30 min at RT, staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. Positive Control: Lung (macrophages). |
| Background | Tartrate-resistant acid phosphatase (TRAP) is a basic iron-binding protein with high activity towards phosphoproteins, ATP and 4-nitrophenyl phosphatase. It is detected in human alveolar macrophages, osteoclasts, spleen and liver. Its expression is increased in spleen and monocytes of patients with Gaucheru™s disease; spleenocytes and circulating leukocytes of patients with hairy cell leukemia; spleen of patients with Hodgkin's lymphoma and in the sera of patients undergoing active bone turnover. |
