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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-345310 |
AP07652PU-N |
ACE2//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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ACE2 |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Paraffin Sections, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 50 ug | | Reactivity | Human, Mouse | | Presentation | Aff - Purified | | Applications | Paraffin Sections, Western blot / Immunoblot | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Not USA/Canada | | Synonyms | Angiotensin-converting enzyme 2 | | Swiss Prot Num | Q9BYF1 | | Immunogen | Synthetic peptide corresponding to amino acids near the center of human ACE2. | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer. Dilute only prior to immediate use. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | |
| Format | State: Liquid purified IgG fraction. | | ? | Purification: Immunoaffinity Chromatography. | | ? | Buffer System: PBS containing 0.02% Sodium Azide as preservative. | |
| Specificity | This antibody reacts with a peptide corresponding to amino acids near the center of ACE2. | | Add. information | Family: Protease. Subfamily: Metallopeptidase M2. | | Application | Immunohistochemistry on Paraffin Sections: 2.5 µg/ml. Western Blot: 0.5-2 µg/ml. | | Background | Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology . In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently, ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. | | Concentration | 1.0 mg/ml | |
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