| Catalog Number | GTX102975 |
| Product Name | Aconitase 1 antibody |
| Full Name | aconitase 1, soluble |
| Product Description | Rabbit polyclonal antibody to Aconitase 1 (aconitase 1, soluble) |
| Synonyms | ACONS | IREB1 | IREBP | IREBP1 | IRP1 |
| Background | Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5 UTR of ferritin mRNA, and in the 3 UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. [provided by RefSeq] |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 497 and 693 of Aconitase 1 |
| Antigen Species | Human |
| Tested Applications | Dot blot |
| Application Note | Further validation in progress. |
| Specificity | This antibody is specific to the Protein antigen from Aconitase 1. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | Target recombinant protein |
| Target | Aconitase 1 |
| Predicted Target Size(KDa) | 98.41 |
| Cellular Localization | Cytoplasm |
| Form Supplied | Liquid |
| Concentration | 0.56 mg/ml |
| Purification | Purified by antigen-affinity chromatography. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
