| Catalog Number | GTX96195 |
| Product Name | ACVRL1 antibody |
| Product Description | Mouse polyclonal to ACVRL1 |
| Synonyms | ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3 |
| Background | Activin A receptor, type II-like 1 (also called activin receptor-like kinase 1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The protein (sometimes termed ALK1) shares similar domain structures with 3 other closely related ALK proteins (ALK2, ALK3, and ALK4) that together form a subfamily of receptor serine/threonine kinases. ACVRL1 is most highly expressed in human placenta and lung. ACVRL1 deficiency causes hemorrhagic telangiectasia type 2 (HHT2; MIM 600376) also known as Rendu-Osler-Weber syndrome 2 (ORW2). |
| Clonality | Polyclonal |
| Host | Mouse |
| Immunogen | ACVRL1 (AAH42637, 22 a.a. ~ 119 a.a) partial recombinant protein with GST tag. |
| Antigen Species | Human |
| Tested Applications | ELISA, Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | For ELISA (tested with immunogen): Use at an assay dependednt dilution. For WB: (tested against immunogen): Use at an assay dependednt dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. |
| Specificity | Not tested |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | Recombinant protein |
| Target | ACVRL1 |
| Form Supplied | Liquid |
| Purification | Unpurified |
| Purification Note | From polyclonal serum |
| Storage Buffer | Antiserum containing 50% glycerol |
| Storage Instruction | Upon Receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Notes | Antibody reactive against recombinant protein with GST tag on ELISA. Please enquire about availability of recombinant protein. |
| Manufacturer & Mfg Part# | Abnova H00000094-A01Only available to US end-users. Not available outside of the US or for resale inside of the US. |
