| Synonyms | ADAMTS-5, ADAM-TS5, ADAMTS11, ADMP2, Aggrecanase-2, ADMP-2, |
| Swiss Prot Num | Q9UNA0 |
| Immunogen | Synthetic peptide corresponding to N-terminal domain of human ADAMTS5 - KLH conjugated. |
| Product Type | Antibodies |
|
| Immunogen | Swiss Prot Num: Q9UNA0 |
| ? | Remarks: Rat Identity: 80% Rat Similarity: 90% |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
|
| Format | State: Liquid purified Ig fraction. |
| ? | Purification: Immunoaffinity Chromatography. |
| ? | Buffer System: PBS containing 0.09% Sodium Azide as preservative. |
|
| Specificity | This antibody reacts N-terminal domain of ADAMTS5. |
| Application | Immunohistochemistry on Paraffin Embedded Tissues: 14 µg/ml. |
| Background | ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a 'met turn,' a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif. At least four transcript variants have been reported. ADAMTS5 has been implicated in inflammatory joint diseases. |
| Concentration | 1.0 mg/ml |
