| Synonyms | Meltrin alpha |
| Swiss Prot Num | O43184 |
| Immunogen | Synthetic peptide corresponding to the amino terminal end of active ADAM-12 |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
|
| Format | State: Liquid purified Ig |
| ? | Purification: Affinity chromatography |
| ? | Buffer System: PBS containing 0.05% Sodium Azide and 50% Glycerol |
|
| Specificity | This antibody is specific for ADAM-12, (A Disintegrin And Metalloproteinase 12). It recognises epitopes in the aminoterminal domain and therefore recognises both ADAM-12S and ADAM-12L. |
| Application | Western Blot: 1/1000; Under reducing conditions this antibody detects both latent and active forms of ADAM-12. |
| Background | Two forms of human ADAM-12 have been described, ADAM-12S and ADAM-12L (short and long forms respectively). ADAM-12L is a large, membrane-bound protein. The short form is a soluble, alternatively spliced form lacking the transmembrane and cytoplasmic domains. ADAM-12 is expressed mostly in muscle and bone, but can be found in placenta, osteoblasts and a number of tumour cell lines. It is reported to be involved in myoblast fusion. |
| Caution | (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. |
| Concentration | 1.0 mg/ml |
